Phototoxicity
Phototoxicity refers to a non-immunologic skin reaction that occurs when certain chemical compounds present on the skin surface are activated by ultraviolet (UV) radiation, particularly UVA. This reaction may result in cutaneous manifestations such as erythema, edema, blistering, and, in severe cases, burns.
One of the most well-known classes of phototoxic compounds is furanocoumarins, naturally occurring constituents found in certain essential oils, especially in cold-pressed citrus oils. It is important to note that not all furanocoumarins exhibit phototoxic properties. However, compounds such as psoralen, methoxsalen, geranial, and oxidized coriandrol derivatives have been identified as potential photosensitizers.
When essential oils containing high concentrations of these compounds are applied topically, especially in undiluted or improperly diluted forms, the skin may develop phototoxic reactions upon subsequent exposure to sunlight or artificial UV light. Symptoms typically appear within 24 hours and may peak between 36 to 72 hours post-exposure. In some cases, residual hyperpigmentation may persist for several weeks or months.